Hopefully people are going to start looking at the vitamin D. I really like that. Yeah but I mean I hadn't come over here. The problem is, is that melanin also blocks your your ability to produce vitamin D, but if you're out in the sun all the time, you know, in a place where you're getting UVB radiation, it's not a problem. I wonder if she has that. As you mentioned, there is you know, you don't want to take too much vitamin D, you don't want to like, you know, overdose on it. You could bake, you could grill, you could do literally any kind of cooking you want to do. And I was like, this is amazing. You can grill on them, you can barbecue, you could bake, you can you could cook slow, you can grill things fast. It's changing five percent of the human genome. Really? Good. He woke me up. Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology. OK, what is so good about. Researchers have found an antibody in winter that effectively attached itself in neutralise spike protein in sars-cov-2 one in Cove. We have stocked you up. When I lay down, it closes the airway. She didn't. Like, I don't know what the x rays will look like. Like, you know, I've just I've got like a bad oral microbiome or something that I've just for four years or I don't know, I shouldn't have cavities because I don't eat sugar. I mean it was like I finally got a jump rope and it came in right when the beaches opened up. I think there's I they they isolated from humanised mice or something. Just constant wear for years then. Oh, my son doesn't want to take he doesn't want to sleep ever. Another study demonstrated the potential of vitamin D as a clinical benefit in population-based trials. Like, I don't think that's odd. It's a two person sauna and. Like you want. But, you know, that's another possibility for sure. It would be so scared. Yeah. No, no, no. And it's it is just hard to get them motivated to go exercise. But we handle it like friends. And so if you look at these these common cold studies, there's like randomized meta analysis, randomized controlled trials, an analysis of them. That's so crazy. It's a game changer. So it's not like damaging your own cells. Someone might have done that study. Is there any speculation as to why these large groups there was another one that was a meatpacking plant where most of the people were asymptomatic as well. You get a room full of people. There's your immune system. But but the popcorn. I don't I don't have that same perspective. They're wearing T-shirts, they're wearing shorts. It's hard to sleep probably when you're in those. Two hundred milligrams. He it's some claim it's a cultural thing. Cloudy all the time. you must be in the tropical central belt, all of us in canada feel really bad for you. It's kind of like you read these stories. It has to be shown like this isn't something that people can just, you know, take it home and think I'm protected. It's wintertime. I like it. I've done it before coming. Monthly didn't work there. We didn't talk about that. I mean it hurts, everything hurts. The leader and senior research in Finland. Yeah. So they become like, you know, you get like a higher viral load and then you don't have antibodies to neutralize it. But also maybe that is not feeling well because vitamin D deficiency plays a factor in that as well. So I found that really interesting. So I think that people designing clinical studies like they need that needs to be in their mind before they design their trial. Like, why can't you wear a swimsuit? Maybe that's why they're shittier, you know? They're twenty eight times more deficient in vitamin D than than Caucasians. I you know that's dialed in and I'm definitely like do the right. And he's like, no, I go, listen, I have to go, but you got to do something about it. Joe Rogan Experience & Dr. Rhonda Patrick on Fasting. You know, it's well, it's it's important. And the reason for that, scientists think, is because basically. Severe covid-19 illness that's not been shown like it's not been shown at all, so but it's interesting, right? And I'm typically like you know I'm like my, my meals that are like, you know, low carb, like I usually like I eat more like a paleo ish diet, you know. Have you ever measured your heart rate during it? So it's that Bertsch you know what they're whipping. Wow. And the sauna, but but I need to be better about resistance training for sure. So like adults, like it reduces the common cold, like two grams can do something like twenty, reduce the duration by twenty percent or something in children's emergency. And and the reason that's important is because a lot of studies looking at oral vitamin C consumption and like, for instance, the common cold incidence, the common cold really depends. It's a lot. OK, thanks for being here. The UV light from the sun is just as important. Oh, yeah, for sure. So we've been doing intravenous vitamin C and Glutathione and a bunch of other stuff. Do you know about these red light machines that people stand in front of? Like it's not the same at all as before that was known. I know at least three that I think his name is Dr Michael Bush. I don't want to make people feel bad. Given intravenous vitamin C, it's generating peroxide, but there's no oxidative damage happening in people's like lymphocytes and stuff. Do you like it? And, you know now. People are more likely to make change when like you can't like if something they have to be motivated to make the change themself or just otherwise it doesn't work, you know. It's like so taxing. I'm like, bro, I so I did that 200. I was terrified and it thankfully has not been that bad. And I freak out and I scream. Due to her influence, a lot of people are now including vitamin stacks as a daily health staple. Has it not been well understand for like 20 years that not getting any sun has negative impacts on how you feel? Ninety proof Franklin County, Kentucky, Buffalo Trace, American family owned and fiercely independent. It was like the worst thing ever. Once I started doing it during the lockdown, one of the things I know is the runs that I do, the last hill is fucking brutal and I always finish on this last hill. Like, you know, like when you're working out hard, like you sometimes require, like, more more sleep. Pro inflammatory thing. I think the first time I came on your podcast, like, I know many years, it's been it's been a while, but I talked about this on years. Yeah, I use it every day. Attend live or listen in our exclusive member-only podcast The Aliquot. Why not test that? But I mean, I think there's so many things there's just there's so many factors that a lot of data that needs to be passed out for sure. It's cold. I know. Yeah. But this virus doesn't have any symptoms. You know, after doing just so much, of course, the past couple of months, I've been nothing but like reading about the immune system and trying to understand, of course, this new virus, sars-cov-2. But here's the interesting thing about this virus, is that it so this is one of the major things multiple studies have been looking at, like, you know, just immune variability. It's somewhere in the range in many studies of 70 plus percent of people that get in contact with this are asymptomatic, but test positive for the disease. Affecting the aging process. You chew gum. And that makes it makes all sorts of problems. That's when I love it. I was like I gave myself TMJ. So you're not getting any vitamin D. Yeah. She has been making the rounds on many popular podcasts, including the Joe Rogan Experience due to her expertise in anything regarding supplementation. Respected master distiller Harlan Wheatley is in charge and he also makes craft vodka named after him Wheatly Vodka. But, you know, I think I think the bright light exposure for him, you know, taking him out in the morning is really important. Right. I try not I try not to judge like I really do. And from that you hang from the waist. SNEP So we we're our genetic report that we have, like we've got one that's like a new viral. This strategy that you guys have, you're not adjusting and adapting. And like, I still like to this day. And I'm clear and I did that right when I got back from Jacksonville because I'm in Florida, even though everybody's been tested, I'd like to get tested again. And it just, you know, it could be more it could be it can lead to death. According to NHANES data, older adults were 63 % more likely to have vitamin D deficiency and 46 % more likely to have vitamin D insufficiency than young adults while other sources have suggested a 70-year-old may produce 4 times less vitamin D than their former 20-year-old selves. Month to month and a half or whatever, and we kind of like my team and I just drove in and put together an article, released a podcast on it, a video where we just kind of covered everything. 1 year ago. We really have to stockpile food. And you can't say it does this. Joe Rogan and Rhonda Patrick cover a wide range of topics from pros . You're hanging by your ankles and decompressing your spine. Generally speaking, one thousand I use will raise your blood levels by about five nanograms per minute. Rate your immune system and strengthen it is important. So the heat shock proteins directly can activate urinate immune system, but they also have antiviral activity against influenza virus. But there there have been studies at least were localized heat on people that had a limb immobilized. I'm like, hell no, I'm not going to take benzoate that's, you know, been shown to like cause dementia. And the only solid evidence I could find on negative effects of fluoride on the brain are in utero, meaning pregnant women. She has done extensive research on aging . It plays a big role in protecting that's been shown in multiple studies like. That game we've been doing as Eilerts on it. Of course, right now, it's like you can't go to Alaska. It is. He's at UCSF. So that's that's the thing right there, the machine. Look, and people are shittier over there. Yet. I usually use it at home, but sometimes I use it here when I like, right after workouts like if I workout I try to get a workout here before, you know, like before do podcasts and I'll time it so they have an extra hour so I can get in the sauna. Something like a month, I think. And and then just more and more studies came out where it was not not only not helpful, it was, you know, toxic. Just the conversations you have with people that are into releasing toxins. There was this weird. It is taking five. I mean, there are those people to. You go crabbing, you'll find crabs, cycling, exploring rock pools. This is not the horrible tragedy. 6 hours? We need, you know, you know, people to repeat stuff. You'll find it. So I started doing research on xylitol while I was looking for alternatives to stuff like Tom's of Maine. So many debates about it. And that's then raising our core body temperature through that mechanism. There it is. But anyways, it was my first time camping, like outside, like not in like like I've been to Yosemite, but I like staying in a cabin. The I think the entire disease, it's out of their system. But the the reverse hyper. Yeah. You know, so like I think that's a really cool thing about this, Onna, is that you can get people that are disabled, people that can't go for a run. Totally have it. So there's been studies were like you could do a two minute cryo, whatever the average temperature, it's really cold, minus two for it is something like that. It's like like it's like my my teeth get dirtier. And I was like, says, you have to you can't wear any clothes or some suit or anything. Right. But what is known is that people with type of blood are are less susceptible to contracting covid-19 that's that's definitely known. He's an angel. With this shelter in place because I like to do outdoor runs and I don't have a treadmill or anything like that. Because vitamin D is a fat soluble vitamin and it's less it's been shown to be 50 percent less bioavailable. She's amazing. Yes I think so. It's on a tent. It has to be something you can just, you know, do it when you need to find a trainer, just find someone that can I mean, you can learn a lot online, but you have access to resources. About 40 to 50 could be like there's probably a range of friends. So sleep is so important, but those poor people that it's going to be one of the worst things for your nurses, like doctors, anybody, the first responder, health workers, anybody is working the late shift. So how would one do a randomized control study on vitamin D in people that have covid-19? That company got a lot of shit for their claims. Legal Zoom's online resources make it easy to get started. But sometimes you've got to like, look at the full body of data. And Japan has a very low mortality rate, correct? I just I don't think that it's totally accurate, considering my only real way to measure that is those little suction. It doesn't do anything. No, it's not that embarrassing. Right. Thanks. So the ginger lemon does. She has heavily investigated the role of Vitamin D on brain function, behavior, hormones, and immune function. And that's that's what, you know, is happening at the hospital and in New Jersey. Can we can we get into vitamin. So, you know, I thought, why not try it? Yeah, it's interesting. Let's quarantine the people who are sick. I've tried it before. So that's terrible. Dr. Rhonda Patrick (@foundmyfitness) has a Ph.D. in biomedical science and is an expert on nutritional health. So other nearby cells by secreting all this stuff. I think it was cycler. And then there's another thing by teeter. It bothers me when people like, well, then don't go on Twitter, period, because most people are unhappy or YouTube. With all due respect, because I love the guy, but he's riding the air time machine in a fucking sauna. But also it's been shown that the hydrogen peroxide does not damage the normal cells like normal northie normal healthy people. Was burning my ears and my so we were, it was dry for us so I wasn't, I wasn't experiencing that as much but I had to like get on the floor because like I felt like my hair was going to fall out, like I was burnt, you know, it was just so hot. And then it came back like a couple of months later or like a few months later back when we were home. She's a she was she had done her I think her PhD, either her, I don't know, say psychology, but she had done it with a guy I interviewed on the podcast, Dr. Charles Rosen, who is he's the guy who showed that like a single hypothermic treatment, which was with a device that raised the core body temperature like almost three degrees, could have an antidepressant effect. The RDA needs to be like almost three times as high for them. So the xylitol gum somehow. But the cold shock, you ask me, cold shock proteins, that that hasn't really been measured in humans. Tastes better. Right? I wonder how much the vitamin D deficiency varies depending upon the winter, the winter, it's been shut. Literally the buffalo on the label is not some neutered buffalo. But I was also using the gym sonas. Salt it's so. And so there some people paid extra to like go to this event that. And they're just getting their rocks off there. So there have been there have been quite a few studies looking at children that are asymptomatic, children that have mild symptoms and children that are symptomatic. Right. But you have to be able to adapt to that. It's not like, you know, drugs. I think it's important to be critical. Watch Here. So you don't worry because I wouldn't be able to talk for like a month. So, like like I understand what it's like to not have a sauna and to have to use hot bath. So it's an infrared. Yeah, those are great. Like saying in 104, that's that's pretty hot. You like strap your. Yeah, it's not worth it. So but she's going to measure the effects on on, you know, on depressed patients. But it was created by this guy, Louis Simmons from West Side Barbel. And we're brought to you by legal zoom. So heat, shock proteins which do like amazing. That's similar to what we have. I'm not using like the best of terms, but neuroplasticity is something along those lines. I eat the shit out of that stuff. It's a fantastic grill and it's so versatile. It makes a big difference. But it does. It's a free one where we're kind of like putting some of these interesting snips which don't mean anything. So I thought that was really interesting. And I think that personally there has been a trend. Ropin. And, you know, in addition to, like repurposing drugs, monoclonal antibodies, you know, being able to basically identify antibodies that do neutralize sars-cov-2 virus, whether they come from llamas or humans, you know, and basically identify the specific antibody that can bind to that spike protein that you just mentioned, which is that region. Like humidity, like the higher the more humid, the better that was. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc.

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